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KMID : 1059520110550060960
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Journal of the Korean Chemical Society
2011 Volume.55 No. 6 p.960 ~ p.968
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Synthesis and Antimicrobial Activity of N-[2-(aryl/substituted aryl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide
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Asha B. Thomas
Rabindra K. Nanda
Lata P. Kothapalli
Avinash D. Deshpande
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Abstract
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A series of isonicotinyl hydrazones and their 4-thiazolidinones have been synthesized by condensation of isonicotinic acid hydrazide with various aromatic aldehydes to yield Schiff’s bases, followed by the cyclocondensation of Schiff’s bases with 2-mercaptoacetic acid to yield their 4-thiazolidinones. The synthesized compounds have been characterized by their elemental, analytical and spectral studies. All these compounds were evaluated for their invitro antimicrobial activity against a spectrum of non-resistant and resistant microbial organisms. These studies proved that compounds 5e,i against B. subtilis; 5e,f,h against B. anthracis; 5g,i against S. aureus showed good activity at lower concentrations. Compounds 5d- 5i displayed significant activity against resistant strain of K. pneumonia with minimum inhibitory potency in the concentration range of 2-16 ug/ml.
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KEYWORD
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Antimicrobial activity, Microwave irradiation, Sonication, 4-thiazolidinones, Resistant bacterial strains
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